MYXOPAPILLARY EPENDYMOMA

Treatment for Ependymoma

Each patient’s course of treatment for Myxopapillary Ependymal tumors will depend on the individual and the location of the tumor. Surgery and radiation treatment are the two primary treatments utilized to treat Myxopapillary Ependymoma tumors. Adjuvant treatment for MPE is crucial since the majority of Myxopapillary Ependymomas are situated in areas where total resection after surgery becomes less possible. The nature and location of the tumor will provide information about the possibility of any postoperative complications.

After complete tumor excision, the long-term survival rate in adjuvant therapies, which combine radiation and surgery, was about 40 percent. Surgeons use the conventional treatment to remove Myxopapillary Ependymomas by surgery combined with irradiation to the affected region because the probability of recurrence with only surgical treatment occurs too often. It goes without saying that assessing the state of adjuvant therapies can lead to the development of success by increasing positive results.

The Categories of Ependymomas

Healthcare providers rate ependymoma on a scale of 1 to 3. Grade 1 tumors are the slowest growing and grade 3 tumors are the fastest growing. There are different types of ependymoma, including:

Grade 1:

A grade 1 tumor called a subependymoma develops close to the ventricles, which house the cerebrospinal fluid. Adults are more likely than kids to experience it. Adult men appear more likely than women to develop grade 1 Myxopapillary Ependymoma in their lower spinal cord.

Grade 2:

The most prevalent ependymoma is the classic kind (grade 2), which can affect both adults and children.

Grade 3:

The grade 3 tumor anaplastic ependymoma frequently develops close to the base of the brain and spreads to different regions of the brain. After treatment, these cancers frequently recur.

Symptoms of Myxopapillary Ependymoma

Myxopapillary Ependymomas have a non-specific clinical appearance that compares to other intradural tumors in the area of the filum terminale, which lies underneath the spinal cord. The tumor’s size, location of presentation, and local expansion all have an impact on the symptoms associated with it. Clinically, Myxopapillary Ependymomas progress slowly. The majority of patients come with the following vague symptoms and wait months to years for a diagnosis.

• The most common patient complaints consist of back pain that worsens at night and when resting.
• The most common patient complaints consist of Motor, sensory, urogenital, and gait problems
• Other signs include scalloping of the vertebral body, expansion of the neural foramina, and scoliosis.
• Hemorrhage can cause the symptoms to suddenly worsen, including leg weakness and sphincter abnormalities.

Initial Treatment of Myxopapillary Ependymomas

Radiotherapy and surgery provide two major methods of treating Myxopapillary Ependymoma tumors. In order to get a histologic diagnosis and remove most of the tumor, surgery becomes an essential step in treating the primary spinal ependymoma. In circumstances where a tumor does not spread, studies reveal that surgery produces the best results.  Radiotherapy provides an adjuvant to surgery, and when doctors believe surgery should not be performed, this therapy becomes the primary form of treatment.

Surgery

Surgically removing a myxopapillary ependymoma from the spine can be a complex procedure due to the tumor’s location and potential involvement with nearby structures. However, with appropriate surgical planning and the expertise of a skilled surgeon, the procedure can be performed successfully. Here are some important points to consider regarding the surgical removal of myxopapillary ependymomas:

• Tumor Location: Myxopapillary ependymomas typically occur in the lower part of the spine, most commonly in the lumbar region. The tumor may arise within the spinal cord itself or extend into the surrounding structures, such as the nerve roots or spinal canal. The precise location and involvement of adjacent structures will influence the complexity of the surgery.
• Surgical Approach: The choice of surgical approach depends on factors such as tumor size, location, and the patient’s individual characteristics. The two main approaches used for spinal tumor removal are the traditional open approach and minimally invasive techniques. The surgeon will assess the situation and determine the most appropriate approach to maximize tumor removal while minimizing potential risks to the surrounding structures.
• Surgical Considerations: During the surgery, the primary goal is to achieve complete resection of the tumor while preserving neurological function. However, the surgeon must exercise caution due to the tumor’s proximity to critical structures, such as the spinal cord and nerve roots. In cases where complete resection is not feasible without risking neurological deficits, a partial resection may be performed, followed by additional treatment options such as radiation therapy.
• Postoperative Care: After the surgery, patients typically require close monitoring and postoperative care to ensure proper healing and recovery. This may involve pain management, physical therapy, and close follow-up with the surgical team to monitor for any potential complications or tumor recurrence.

Myxopapillary Ependymoma Treated with Adjuvant Radiotherapy

Surgical resection is considered the treatment for MPE, but adjuvant radiation therapy (RT) has helped prolong progression-free survival in pediatric and adult patients. RT also provides patients with avoiding the tumor’s recurrence after surgery. Also, the use of 3D conformal radiation or IMRT is appropriate and is under investigation. In addition, a dose of 5400 cGy is suitable for spinal Myxopapillary Ependymoma. A number of studies have examined the effects of RT on the treatment of MPE in adults and children.

They showed that RT was highly effective in controlling residual, metastatic, and/or recurrent disease and that routine adjuvant RT could improve outcomes in pediatric MPE. On the other hand, the degree of resection correlates with outcomes following MPE resection, but the impact of the capsular breach remains uncertain. However, Abdulaziz and his team looked at the significance of capsule integrity after Myxopapillary Ependymoma excision. They discovered a strong association between Myxopapillary Ependymoma recurrence and capsular violation.

Pediatric Myxopapillary Ependymoma Treated with Adjuvant Radiotherapy

Successful treatments for pediatric patients continue as a difficult challenge as they typically have lower outcomes. Even after GTR of the tumor, several publications recommend using adjuvant radiation in pediatric patients. 100% of patients survived when GTR was combined with adjuvant RT. Therefore, in children with Myxopapillary Ependymoma, RT becomes necessary as the next step after GTR.

In a related investigation, Doctors studies the impact of adjuvant RT in 16 juvenile MPE patients. The first form of treatment for all patients was either GTR or a subtotal resection (STR) operation. As a result, doctors concluded that pediatric patients with MPE should undergo adjuvant RT following surgical resection since it improved significantly improved survival rates. Furthermore, the survival percentage for GTR patients was close to 100%. However, the probability of survival with STR plus radiation therapy was 91%.

Other Adjuvant Therapy

Temozolomide, a drug used to treat glioblastoma, recently reported scientific information about it being effective with low-grade spinal cord gliomas, including spinal cord intramedullary ependymoma. However, at this time, scientists and doctors do know if TMZ is effective for Myxopapillary Ependymoma. To this end, TMZ has been presented as a possible option for adjuvant therapy in multiple recurrent Myxopapillary Ependymomas. TMZ showed significant efficacy in recurrent spinal cord Myxopapillary Ependymoma.

Conclusion

As previously stated, Myxopapillary Ependymoma tumors that are located in or on the spine are complex medical problems that require skill and expertise to be treated.  The surgeons at the Southwest Scoliosis and Spine Institute have the knowledge, skills, and abilities to treat these tumors. With offices in Dallas, Plano, and Frisco, Texas, the doctors at the Southwest Scoliosis and Spine Institute specialize in the diagnosis and treatment of spinal conditions, including scoliosis, kyphosis, and other spinal deformities.

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National Institute of Health: Myxopapillary Ependymoma